Substitution at R3 using a halogen or alkoxy group (74f–74i) resulted in a slight increase in mobile potency with the halide analogs (74g–h) displaying highest the potency from the group. Further more optimization brought about the discovery of 74i–j, with 74k as probably the most active compound during the sequence https://raymondrmdrj.eedblog.com/31525056/considerations-to-know-about-indazole-ring-formation