The recognised impact of those PTMs on ATXN2’s perform and SCA2 pathogenesis stays constrained. In other polyQ ailments, several scientific tests recommended that proteolytic cleavage of polyQ proteins could play an important position in pathogenesis [36, forty five]. Aligned with this concept, the presence of an enriched forty two kDa fragment https://peterp877alw0.blogsvila.com/profile