Lifetime-threatening respiratory despair and Loss of life have happened in small children who gained codeine. The vast majority of claimed circumstances happened subsequent tonsillectomy and/or adenoidectomy and many of the kids had evidence of staying extremely-rapid metabolizers of codeine on account of a cytochrome P450 (CYP) 2D6 polymorphism (see WARNINGS, https://wockusa.com/product/fentanyl-100-mcg-hr-transdermal-patch/