Chemotherapy was potentiated by E7449 and single agent had substantial antitumor exercise in BRCA-deficient xenografts. In addition, E7449 inhibited Wnt/β-catenin signaling in colon most cancers mobile strains, likely through TNKS inhibition. In step with this likelihood, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and substantially altered expression https://peterf196wbf0.tdlwiki.com/user