Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other indicators from the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have identified recurrent mutations in genes regulating tumor mobile-microenvironment interaction... https://branchg689vtq7.cosmicwiki.com/user