A single specially intriguing compound is LDN-27219. While most tTG inhibitors are intended to bind to the protein crosslinking active web-site, LDN-27219 rather binds into the nucleotide binding pocket from the enzyme when it is in its closed-state conformation, and stabilizes that conformation to avoid crosslinking activity.78 Schneider et al https://griffincozjv.blogars.com/30697904/ldn-27219-protein-kinase-targeting-things-to-know-before-you-buy