Opioid activity is due to equally reduced affinity binding on the guardian compound and higher affinity binding of the O-demethylated metabolite M1 to µ-opioid receptors. In animal versions, M1 is approximately 6 periods extra strong than tramadol in developing analgesia and two hundred instances extra potent in µ-opioid binding. Ovaj https://ernestz085wdi1.wikidirective.com/user