If a dad or mum with the proband is understood to have the pathogenic variant recognized from the proband, the chance into the sibs of inheriting the pathogenic variant is 50%. As a result of minimized penetrance, sibs who inherit the pathogenic variant might or might not create aHUS (see https://baling-wire77765.actoblog.com/34478872/the-air-handling-units-ahus-diaries